No, smoking weed once is not likely to cause immediate death. However, there are potential risks and negative effects associated with using marijuana, even on a single occasion.

For instance, smoking weed can impair your judgment, coordination, and reaction time, which can increase your risk of accidents and injuries. It can also cause short-term memory impairment, anxiety, and paranoia in some people.

Moreover, smoking marijuana can be particularly risky for individuals with certain health conditions, such as heart disease or respiratory issues, as it can increase heart rate and cause breathing difficulties.